The NeuroAnimation™ technology behind GrowYourBrain works through a vascular mechanism—increased blood flow stimulates the growth and repair of new neuronal structures in your brain.

During gameplay, NeuroAnimation significantly increases blood flow to critical regions:

• The dorsal and ventral premotor cortex

• The hippocampus (your memory center)

This surge in oxygenation is multiples of what traditional therapy provides, fueling neural repair and directly contributing to measurable growth in brain volume.

Proven Results

Johns Hopkins researchers documented 4-6% hippocampal expansion in adults—growth in memory regions that typically shrink with age. MRI-validated. Reproducible. Real.

This advancement has led to therapy that is twice as effective as standard care—boosting processing speed, improving executive functions in healthy older adults, and amplifying cognitive and motor recovery in stroke survivors beyond what traditional therapy can achieve.

Clinical Evidence

NeuroAnimation represents a new category of therapy: high-intensity, high-dose, cognitively-enriching treatment that delivers true cognitive-motor strengthening and recovery.

Key Findings

In acute stroke patients, NeuroAnimation has been shown to be twice as effective as traditional rehabilitation. Outcomes from the SMARTS2 trial show statistically significant ARAT (Action Research Arm Test) gains of 7.3 points—a benchmark that exceeds what standard rehab achieves.

These same brain regions are impacted by various neurological diseases. Clinical trials are ongoing to measure the impact of this technology across multiple conditions including Parkinson's, traumatic brain injury, and dementia.

Research & Clinical Trials

STROKE AND PARKINSON'S BENEFITS:

• NeuroAnimation is 2x as Effective as Standard of Care (SMARTS2, ARAT)

• NeuroAnimation is 2x as Effective as Standard of Care (2nd Study, ARAT)

• NeuroAnimation improves cognitive and motor function in Parkinson's patients

• Intensive Upper Limb Rehabilitation Goes Beyond Standard of Care

OTHER NEUROLOGICAL BENEFITS:

• NeuroAnimation Users Felt a Sense of Accomplishment, Immersion, and Exercise

• Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury (OCEANS-TBI)

• Therapists Noted NeuroAnimation Resulted in Functional Task Benefits and High Levels of Patient Engagement

WHY STANDARD CARE ISN'T ENOUGH:

• High-Dose, High-Intensity Stroke Rehabilitation: Why Aren't We Giving It?

• Little to No Evidence That Repetitive Task Training Improves Arm Function

• Task-Specific Training Doesn't Harness Plasticity Window of Opportunity

• Little Evidence For Standard-Doses of Physical Therapy Post-Stroke

Why Standard Care Falls Short

The clinical history of cognitive-motor recovery after brain injury reveals an important truth: standard rehabilitation does little to reduce impairment beyond what the body naturally recovers on its own.

The Limitation of Traditional Approaches

Traditional rehab focuses on compensatory strategies rather than true healing. It teaches patients to work around their limitations instead of eliminating them.

After a stroke affects motor function, standard therapy teaches patients to adapt—using the non-dominant hand for tasks the affected hand can no longer perform. While this approach aids independence, it overlooks the brain's capacity for neuroplasticity and genuine repair.

What Research Demonstrates

Emerging science demonstrates that practicing full-range, multi-directional movements in high quantities within an enriched environment is far more effective in restoring smooth, coordinated, and complex motor function.

NeuroAnimation delivers this approach—and produces results that standard care cannot match.

Mechanism of Action

The NeuroAnimation mechanism of action is vascular. Increased cerebral blood flow has been shown to stimulate neurogenesis and angiogenesis in targeted brain regions. During gameplay, NeuroAnimation significantly increases regional cerebral blood flow (rCBF), specifically targeting the dorsal and ventral premotor cortex and the hippocampus.

Clinical Outcomes

• SMARTS2 Trial: Statistically significant ARAT gains of 7.3 points (p<0.05)

• Hippocampal volumetric analysis: 4-6% increase in hippocampal volume measured via MRI

• Processing speed improvements: Significant gains in executive function metrics in healthy older adults

• Dose-response: High-intensity, high-dose intervention shows superior outcomes compared to standard care protocols

Ongoing Research

Clinical trials are currently underway examining efficacy in:

• Traumatic brain injury (OCEANS-TBI trial)

• Parkinson's disease motor and cognitive symptoms

• Early-stage dementia and MCI

• Pediatric neurological conditions

For detailed study protocols and results, please contact us for our clinical research packet.